A planning committee of the National Academies of Sciences, Engineering, and Medicine will host a 1.5-day public workshop to examine opportunities and challenges in applying precision medicine approaches to understanding and treating brain disorders. The workshop will bring together experts and stakeholders from across sectors and disciplines to explore how advances in biology, data science, drug development, and clinical practice are shaping the future of individualized care for neurological and psychiatric conditions.
Invited presentations and discussions may:

• Highlight case examples where precision medicine approaches have informed research, diagnosis, treatment, and disease reclassification in neuroscience.
• Examine emerging tools and technologies (including biomarkers, multi-omics, computational psychiatry, and artificial intelligence) and their applications across neuroscience research and clinical care.
• Consider barriers and opportunities for implementation, including provider education, patient engagement, payer and regulatory models, data privacy, clinical integration, and potential risks.
• Explore models for academia-industry-regulatory collaboration to de-risk precision drug development in neuroscience.
• Explore cross-disease and holistic frameworks, including how precision medicine approaches can address comorbidities and support a broader brain health model.

A planning committee will develop the agenda for the workshop, select and invite speakers and discussants, and moderate the discussions. Following the workshop, a proceedings of the presentations and discussions will be prepared by a designated rapporteur in accordance with institutional guidelines.