An ad hoc committee will organize an open, two-day workshop to be held in Washington, DC to gain a better understanding of the position of social and behavioral variables in the causal pathways leading to Alzheimer's Disease (AD). Specifically, this workshop will focus on three variables that are of specific relevance to NIA and have high potential to generate intervention or prevention strategies for AD that would be developed by NIA:

· Examine how personality has been convincingly associated with AD, particularly with evidence of an association between conscientiousness and neuroticism (facets of personality) and AD risk.

· Follow-up on the suggestion that socially integrated and engaged lifestyle has been associated with slower cognitive decline and a reduced incidence of AD.

· Examine what is considered to be the most replicated association of a social or behavioral factor and AD as evidenced with educational attainment.
A brief proceedings of the presentations and discussions at the workshop will be prepared by a designated rapporteur in accordance with institutional guidelines.